A study published in Environmental Health Perspectives, the peer-reviewed journal of the National Institute of Environmental Health Sciences has found that prenatal and neonatal exposure to organophosphates may contribute to insulin resistance, obesity and type II diabetes mellitus, by disrupting the development of some cell-signalling pathways in the liver.
The study findings indicate that OPs alter the trajectory of hepatic cell signaling in a manner consistent with the observed emergence of prediabetes-like metabolic dysfunction. Notably, the various OPs differ in their net impact on peripheral adenylyl cyclase (AC) signaling, making it unlikely that the effects on signaling reflect their shared property as cholinesterase inhibitors.
Whilst this study only looked at AC signalling, one wonders if the production of d-chiro-inositol inositol phosphoglycan (DCI-IPG) might possibly be another step in those signalling pathways which is adversely affected.
In the meantime, anyone wanting to reduce the chances that their own children will suffer from insulin resistance would be well advised to consider certified organic food in an effort to avoid unnecessary organophospate exposure.
Adigun AA, Wrench N, Seidler FJ, Slotkin TA, 2009 Neonatal Organophosphorus Pesticide Exposure Alters the Developmental Trajectory of Cell-Signaling Cascades Controlling Metabolism: Differential Effects of Diazinon and Parathion. Environ Health Perspect 118(2): doi:10.1289/ehp.0901237