Fertility forums are full of advice not to take Clomid and vitex together because they cancel each other out, however, information which explains why this might be the case appears to be nonexistant. Whilst it is probably redundant to take both at the same time, there does not appear to be any reason why it would be damaging to do so.
Vitex agnus castus is a herb which is thought to act on the hypothalamus and pituitary glands by increasing luteinizing hormone (LH) production and slightly inhibiting the release of follicle stimulating hormone (FSH). This increases the ratio of progesterone to oestrogen which is very beneficial to women with PCOS as progesterone is almost always low in women with PCOS. It also reduces elevated prolactin levels, which may help to overcome head hair loss, as high prolactin levels can contribute to hair loss.
Clomid, also known as Clomiphene, Clomifene, CC, Clomiphene Citrate, Clomifert, Serophene and Milophene is a drug frequently given to women who are sub-fertile to stimulate ovulation. It increases the body’s production of gonadotropins like follicle stimulating hormone (FSH) & luteinising hormone (LH) through inhibiting oestrogen receptors in the hypothalamus, which in turn inhibits negative feedback.
Clomiphene initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. The first endocrine event, in response to a course of clomifene therapy, is an increase in the release of pituitary gonadotropins. This initiates steroidogenesis and folliculogenesis resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.
Clomid has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. Clomifene appears to stimulate the release of gonadotropins, follicle-stimulating hormone (FSH), and leuteinizing hormone (LH), which leads to the development and maturation of ovarian follicle, ovulation, and subsequent development and function of the corpus luteum, thus resulting in pregnancy. Gonadotropin release may result from direct stimulation of the hypothalamic-pituitary axis or from a decreased inhibitory influence of estrogens on the hypothalamic-pituitary axis by competing with the endogenous estrogens of the uterus, pituitary, or hypothalamus. Clomifene has no apparent progestational, androgenic, or anti-androgenic effects and does not appear to interfere with pituitary-adrenal or pituitary-thyroid function