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Liquorice & Paeony

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Japanese Formula Name: Shakuyaku-kanzo-to

TCM Formula Name: TJ-68, Shao Yao Gan Cao Wan

This is a two-herb combination for relieving pain associated with muscle spasm. It was originally used for muscle spasms following overuse of diaphoretic formulas, and has also been the formula of choice for chronic spasms in the calf muscles and abdominal cramping. It is currently used for a variety of pain presentations. The synergistic combination of the two herbs move Qi and Blood in the Liver and along the Liver and Gallbladder channels. (Fratkin, Chinese Herbal Patent Medicines)

Pharmacokinetic Studies of the Significance of Herbaceous Compatibility of Peony Liquorice Decoction

Wang Wenpinga, Wang Chuijieb, Gu Songc, Cao Qichena, Lv Yupingc, Gao Jingjingc and Wang Shujingc

a Key Laboratory of Clinical Pharmacokinetics of Traditional Chinese Medicine of Liaoning Province, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. Shenyang 110032, China

b Gastroenterology Department, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China

c Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China

Abstract

This study aimed to explore the rationality of herbaceous compatibility of peony liquorice decoction by analyzing the pharmacokinetic parameters of peoniflorin and glycyrrhetinic acid in SD rats’ plasma. A HPLC/MS/MS method was used to detect the concentrations of peoniflorin and glycyrrhetinic acid in plasma of SD rats which were administrated with peony, liquorice and peony liquorice decoction, respecttively. Compared with the rats having single administration of either peony or liquorice, it took less time for the glycyrrhetinic acid in the plasma of rats administered with peony liquorice decoction to reach the peak concentration and its maximum concentration level was also increased. Moreover, the peoniflorin’s peak concentration was increased, and the relative bioavailability was also enhanced. The half-life reduction happened to both peoniflorin and glycyrrhetinic acid. The liquorice promoted the absorption of peoniflorin in peony and enhanced itsĀ in vitro concentration, which in turn induced stronger and more powerful functions from the peoniflorin, such as spasmolysis, pain relief and calmness. The peony had shortened the time for glycyrrhetinic acid in liquorice to appear in intracorporal and had increased the quantity of glycyrrhetinic acid in intracorporal, bringing out the effects of anti-ulcer, spasmolysis, and anti-inflammation. This experiment had proven the rationality of the peony liquorice decoction compatibility in terms of pharmacokinetics.

http://dx.doi.org/10.1016/S1876-3553(10)60020-8

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