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D Chiro Inositol: How Does It Work?

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Buy DCI D Chiro Inositol for PCOS polycystic ovarian syndrome now

“It has been demonstrated that PCOS women who received DCI enjoyed lower free and total cholesterol levels, lower blood pressure, increased insulin sensitivity, and a higher frequency of ovulation.

Furthermore, DCI administration in PCOS women seems to improve BMI (body mass index), WHR (waist-hip ratio) and both systolic and diastolic blood pressure, hence improving the overall physical health of the patient.”

- Galazis N, Galazi M, & Atiomo W. (2011) D-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 27(4), 256-62. PMID: 21142777

D-Chiro Inositol (DCI) is a member of a family of substances referred to as inositols and generally considered to fall within the B vitamin complex.

Buckwheat is a source of d-chiro inositolIt can be found in small amounts in a range of foods such as buckwheat, chickpeas, soya lecithin, pumpkin and pumpkin seeds as well as in the Ayurvedic herb bitter melon (momordica charantia). It is also produced by healthy human bodies from d-pinitol and myo-inositol, both of which are relatively abundant in the average diet.Bitter Melon contains d-chiro inositol

DCI plays an important role in insulin signal transduction in human metabolism as a secondary messenger. Insulin transports the sugar from the blood into the cell where a d-chiro inositol-containing Inositol Phosphoglycan or DCI-IPG converts the sugar into either adenosine triphospate (ATP) to be used as energy or glucagon to be stored for later use.

It is currently thought that many cases of insulin resistance, polycystic ovarian syndrome and even type II diabetes mellitus are caused by a functional deficiency of this substance through both dysfunction of the enzyme which produces DCI as well as an overly efficient method of excreting what DCI is present in the body.

Polycystic Ovarian Syndrome responds well to d-chiro inositol DCIStudies have found that women with PCOS excrete DCI in their urine at 6 times the rate of healthy control subjects, whilst tissue biopsies taken from people with Type II diabetes have shown a significantly decreased level of DCI-IPG in their cells.

Supplementing with d-chiro inositol can help to address the functional deficiency and may increase the amount of DCI-IPG available in the cells to properly metabolise glucose into energy.

Buy DCI D Chiro Inositol for PCOS polycystic ovarian syndrome now

D-chiro inositol improves fertility in women with PCOS

There is early evidence that DCI may also help those with Type II Diabetes Mellitus, however, further clinical trials will be required before this will be known definitively and the effect quantified. For the time being, taking DCI is an excellent way help minimise the risk of PCOS developing into Diabetes.

Human clinical studies have so far shown that DCI supplementation in women with PCOS and those who are insulin resistant can improve a whole raft of symptoms and clinical markers such as:

  • Increasing cellular insulin sensitivity
  • Increasing fertility
  • Improved ovulation frequency by 300%
  • Increased low progesterone levels
  • Reduced serum insulin levels
  • Reducing raised serum androgens (testosterone) both free and total
  • Reducing glycosylated haemoglobin (HbA1c) an indicator of long term sugar levels
  • Reducing plasma triglyceride levels (the amount of fat in your blood)
  • Reducing (bad) LDL cholesterol
  • Increasing (good) HDL cholesterol
  • Reducing raised blood pressure, both systolic and diastolic
DCI D-chiro-inositol for PCOS Polycystic Ovarian Syndrome

Buy D-Chiro Inositol for PCOS here


Buy a 1-month supply of DCI here for just $60. 

(36 grams will provide 1200 mg per day, suitable for a 60 kg/132 lb woman.  The recommended dose is 20 mg/kg.)



Scientific Research:

Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G (1999). “Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome”. N. Engl. J. Med. 340 (17): 1314-20. PMID 10219066.

Nestler JE, Jakubowicz DJ, Iuorno MJ (2000). “Role of inositolphosphoglycan mediators of insulin action in the polycystic ovary syndrome”. J.Pediatr. Endocrinol. Metab. 13 Suppl 5: 1295-8. PMID 11117673.

Larner J (2002). “D-chiro-inositol–its functional role in insulin action and its deficit in insulin resistance”. Int. J. Exp. Diabetes Res. 3 (1): 47-60. PMID 11900279.

Luorno MJ, Jakubowicz DJ, Baillargeon JP, et al (2002). “Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome”. Endocrine practice 8 (6): 417-23. PMID 15251831.

Sun TH, Heimark DB, Nguygen T, Nadler JL, Larner J (2002). “Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls”. Biochem. Biophys. Res. Commun. 293 (3):1092-8. PMID 12051772.

Cheang KI, Essah P, Nestler JE (2004) “A Paradox: The role of inositolphosphoglycans in mediating insulin sensitivity and hyperandrogenism in the polycystic ovarian syndrome” Hormones 3(4):244-251

Baillargeon JP, Apridonidze T, Diamanti-Kandarakis E, Iuorno M, Ostlund RE, Nestler JE (2006) “Altered D Chiro Inositol urinary clearance in women with polycystic ovarian syndrome” Diabetes Care 29(2):300-305

Salley KES, Wickham EP, Cheang KI, Essah P, Karjane N, Nestler JE, (2007) “Glucose Intolerance in PCOS: AES Statement” J Clin Endocrinol Metab 92(12):4546–4556

Cheang KI, Baillargeon JP, Essah P, Ostlund RE, Apridonidze T, Islam L, Nestler JE (2008) “Insulin stimulated release of d-chiro inositol-containing phosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovarian syndrome” Metabolism Clinical and Experimental 57:1390–13

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11 comments to D Chiro Inositol: How Does It Work?

  • [...] hemsida heter My PCOS info och den hittar du här och vill du läsa mera om DCI så finns det info här. Det lönar sig också att läsa på om D-vitaminbrist – nånting som jag inte ens visste [...]

  • Hi there
    Can you take DCI and MYO with Vitex?

  • lara

    Hello, I am of slim to normal build 56kg. I have suffered with PCOS since the age of 15 and I am now 34 with symptoms of; excessive facial hair growth, weight on middle section of my body, irregular periods and severe depression. I suffered body dysmorphic disorder for a number of years as I believed I was morphing in to a man. My question to you is a question I can not find for some reason. There are studies of D chiro inositol reducing testosterone levels which is great, but I am concerned that d chiro inositol will reduce my estrogen levels which will effect be considerably. Any information on this matter will be highly appreciated.

    Many thanks,


  • My PCOS Info

    There is no evidence in the studies that have been done on PCOS and DCI to indicate that DCI would reduce estrogen levels. PCOS is usually a disorder of excess oestrogen, or oestrogen dominance, where the excess is converted into testosterone. Anecdotally, I have taken DCI for 4 years, myself and my oestrogen levels have remained within the normal limit throughout this period. I hope this info helps. If you have any more questions, please let me know. I’m here to help.

  • My PCOS Info

    Yes, you certainly can. They all work quite well together.

  • candice

    Hi there!

    I was wondering where your d-chiro inositol is derived from? Thanks :)

  • My PCOS Info

    Hi Candice,

    It is extracted from carob pods.

    Kind regards,


  • Neha

    Hi Anne,

    I wanted to know how long do you think it would take to know if DCI is making any difference to my PCOS?

    I am 32 yrs old and have PCOS and insulin resistance. I am not fat but I have other issues with my digestion and chronic fatigue. However, for the first time since I was diagnosed 7 years ago, I have not had a period for over two months. I have started a low carb diet recently and started to add some exercise to my routine.


  • My PCOS Info

    Hi Neha,

    According to the studies, you should be able to see significant improvements in your biochemistry within 12 weeks of taking DCI. You should expect to see an improvement in cholesterol, triglycerides, inflammation markers such as CRP, and sex hormones as well as an improvement in glucose tolerance which can be monitored through fasting and post-prandial blood glucose and insulin testing, HbA1c and 2 hour glucose tolerance tests.

    If you have any further questions, please let me know. I’m here to help.

    Warm regards, Anne

  • Breezy

    Hi Anne

    I’m so glad that I found this product for sale within Australia! But do you have or do you know where I can get a combined supplement with both D Chiro Inositol and Myo Inositol, which is more effective than either alone? They have a number of products in America, but none that ship to Australia.

    Thanks so much!

  • My PCOS Info

    Hi Breezy,

    You can buy both d-chiro inositol and myo-inositol powder from me if you wish, however, the research implying that myo and DCI are more effective together in a physiological ratio, is very limited and much of it sponsored by the companies that manufacture those combined supplements. More research from independent researchers is required before one could confidently believe those conclusions in my opinion.

    You can purchase both inositols here:

    Warm regards,


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