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How Do You Know If You Are Deficient In DCI-IPG?

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From Nasrin:

“How does one know that she has a deficiency in DCI-IPG? And how do you correct this disorder?”

DCI D-chiro-inositol for PCOS Polycystic Ovarian SyndromeBuy D-Chiro Inositol for PCOS hereThe only way to definitively determine whether you are functionally deficient in DCI-IPG is to do a muscle biopsy. I don’t believe that this is performed clinically at present, as it’s a reasonably invasive test, but there have been a couple of studies which have performed muscle biopsies from live patients and obtained samples during autopsies of Type II diabetics as part of their investigation into the role of DCI-IPG in insulin resistance.

From a study published in 2008 in the Journal Metabolism Clinical and Experimental by Cheang et al:
“Significantly decreased muscle DCI-IPG bioactivity and decreased total DCI content have been noted in needle biopsies [13] and autopsy specimens [14] from subjects with type 2 diabetes mellitus compared with controls. In addition, DCI-IPG (or P-type IPG) has been shown to be decreased in human term placentas in preeclamptic individuals, who also concomitantly exhibit decreased insulin signaling, when compared with healthy women [28].”

Buy DCI D Chiro Inositol for PCOS polycystic ovarian syndrome nowThe other studies referred to in the paper are:
[13] Kennington AS, Hill CR, Craig J, et al. Low urinary chiro-inositol excretion in non–insulin-dependent diabetes mellitus. N Engl J Med 1990;323:373-8.
[14] Asplin I, Galasko G, Larner J. Chiro-inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol–containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects. Proc Natl Acad Sci
[28] Scioscia M, Gumaa K, Kunjara S, et al. Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2. J Clin Endocrinol Metab 2006;91:709-17. U S A 1993;90:5924-8.

I hope this answers your question.

Clinical signs such as better energy levels, reduced appetite (or even increased appetite) are a good indicator that you do have a degree of DCI deficiency, either through a lack of dietary myoinositol or an inability to convert myoinositol into DCI. Hopefully as your treatment progresses you will resume menstruating. Some women have found that their menstrual cycle either shortens, or if it has been absent, returns within their first 2-4 weeks of treatment with DCI, even if it’s been absent for years.

There is no known way to correct the disorder, in fact, the disorder itself is still being isolated. It appears that some women (especially those from the studies performed in South America) have a deficiency of DCI that is corrected by dietary supplementation with d chiro inositol. A more recent study, in fact the one I quoted from above, resulted in findings that indicate that there is another mechanism of action in IR which may involve a functional deficiency in DCI-IPG which is NOT corrected by dietary supplementation. It’s hard to say, as the study was cut short at only 6 weeks due to them running out of DCI and they did not test levels of testosterone, cholesterol, triglycerides etc – the things that have been found to consistently improve in prior studies.

Insulin resistance, which is really the root of the problem when it comes to PCOS, is a complex problem and there are many things that you can do to improve it. Please check out and for some ideas or feel free to write back with any more questions you may have.

Well this is rather a long-winded and technical response but it is a complex issue. I hope it’s been helpful to you.

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2 comments to How Do You Know If You Are Deficient In DCI-IPG?

  • Annabel

    Hi, I am just wanting to know about Vitex use & anxiety. As I have PCOS and have recently stopped to oral contraceptive pill as I was taking it to help regulate my hormones & treat my anxiety which worked for a few months but it did not last so I thought I would come off the pill and try Vitex but searching the Internet I has read some people’s post about bad experiences with making anxiety worse & causing depression. So now I am scared to try it. Also it seemed that these people may have been using daily doses round the 800mg mark. Would this dose be too much for a women of 43kg as this is my weight?
    Looking forward to your response.

  • My PCOS Info

    Hi Annabel,

    If you have PCOS, a lower dose is likely to be more beneficial. There’s no point in taking more than you need. You could start with 400 – 600 mg per day and see how you go. Vitex usually takes a few months to take effect. That being said, Vitex is an exceptionally well-tolerated and safe herb, with very few reported side effects from even long term clinical studies.

    I have never seen any research indicating a link between taking Vitex and developing or worsening anxiety, but that doesn’t mean it couldn’t happen. Frequently people mistake things that occur in close proximity to another event, such as taking a drug or supplement, as being a result of that other event, when in fact they are an unrelated coincidence. There is an oft-repeated saying in science “correlation does not equal causation”.

    If you have PCOS, I would suggest that you look into taking d-chiro inositol as it treats the cause of the hormonal imbalance instead of just the symptoms. There is also an increasing body of research behind using another inositol, myo-inositol in very large doses in the treatment of anxiety and depression. Perhaps one or both of the inositols may help you.

    Levine J, Barak Y, Gonzalves M, et al. Double-blind, controlled trial of inositol treatment of depression. American Journal of Psychiatry. 1995;152(5):792–794.
    Levine J, Gonsalves M, Babur I, et al. Inositol 6gm daily may be effective in depression but not in schizophrenia. Human Psychopharmacology. 1993;8(1):49–53.

    If you would like copies of any of the studies done on them, just let me know and I can email them to you.

    If you have any more questions, please let me know.

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